SilverCloud® by Amwell® Science

Putting evidence first

At the forefront of evidence-base generation and digital health science
Research Papers

Backed by nearly two decades of clinical research, Amwell®’s team of mental health experts deliver successful outcomes through the market’s most robust evidence-based behavioral change programs, empowering users to take control of their mental health and wellbeing

  • 50+ peer-reviewed published research papers.

  • 4700+ citations.

  • 50+ international presentations at academic conferences.

  • 90K+ participants across all real-world research.

  • 20+ research projects in the works.

Published research papers, citations, presentations at international academic conferences, and research projects continues to grow exponentially each year.

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With research partners across the world,  digital health science and evidence generation is in our DNA.


Translating science into effective digital health solutions

SCH_DG_Research Cards_Implementation science and practice
Behaviour research and therapy | 2015

A Randomized Controlled Trial of an Internet-Delivered Treatment: Its Potential as a Low-Intensity Community Intervention for Adults With Symptoms of Depression

This was one of the first RCTs conducted with our Space from Depression digital CBT programme. The results revealed that Space from Depression, is effective in reducing depressive symptoms in comparison to a waiting list control group, in a community sample of Irish adults. The findings highlighted the potential for the online delivery of mental health interventions to be scalable, accessible and resource efficient solutions for addressing mental healthcare needs.

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SCH_DG_Research Cards_Machine learning and big data analytics
JAMA Psychiatry | 2020

A Machine Learning Approach to Understanding Patterns of Engagement With Internet-Delivered Mental Health Interventions

This study aimed to identify behaviour types based on how people engage with a digital CBT intervention for symptoms of depression and anxiety. The findings suggested that patterns of patient behaviour may elucidate different modalities of engagement, which can help to conduct better triage for patients to provide personalized therapeutic activities, helping to improve outcomes and reduce the overall burden of mental health disorders.

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SCH_DG_Research Cards_Efficacy and effectiveness
Nature’s NPJ Digital Medicine | 2020

A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety

This large-scale RCT showed that digital CBT for depression and anxiety is effective in reducing anxiety and depression symptoms in comparison to a waiting list control group. The findings also demonstrated the potentially cost-effectiveness of digital CBT in the long-term within IAPT. The pragmatic trial design additionally provided important support for the ecological validity of the findings.

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SCH_DG_Research Cards_User experience
Clinical Psychology and Psycotherapy | 2021

Following up internet-delivered cognitive behaviour therapy (CBT): A longitudinal qualitative investigation of clients' usage of CBT skill

This qualitative study demonstrated how clients receiving digital CBT in routine care learn CBT skills during treatment and utilize them in productive ways post-treatment. The findings are consistent with similar research conducted on face-to-face CBT, and more generally, they support the position that the acquisition and application of CBT skills is a core component and mechanism of effect maintenance in CBT-based treatments.

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SCH_DG_Research Cards_Efficacy and effectiveness-1
JMIR Formative Research | 2021

Dropout From an Internet-Delivered Cognitive Behavioral Therapy Intervention for Adults With Depression and Anxiety: Qualitative Study

This qualitative study demonstrated how patients who drop out of treatment can be distinguished in terms of their change in motivation: those who felt ready to leave treatment early and those who had negative reasons for dropping out. These two groups of participants have different treatment experiences, revealing how there is a difference between what we typically label as a dropout and what should actually be considered a dropout.

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SCH_DG_Research Cards_Efficacy and effectiveness-2
Clinical Psychology and Psycotherapy | 2022

Durability of treatment effects following internet-delivered cognitive behavioural therapy for depression and anxiety delivered within a routine care setting

This study investigated post-treatment relapse and remission rates 3, 6 and 9 months after completion of an acute phase of a clinician-supported digital CBT, within a routine care setting. We found that 70.8% of those who met the criteria for recovery at the end of their treatment, still met the criteria for recovery at 9 months post-treatment. The results add to the scarce literature on the durability of the effects of digital CBT treatment in routine care settings, where patients are not typically followed up after completing a course of treatment.

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Leaders in the science of digital health care

Meet Our Team


Derek Richards, Ph.D.

Chief Science Officer

Dr. Richards is part of the executive team at SilverCloud® by Amwell. As Chief Science Officer, Derek leads on the strategic research objectives for the company. He is also the director of the E-mental health research group in the School of Psychology, Trinity College Dublin. Since 2002 he has been extensively involved in clinical research, development and implementation of technology delivered interventions for mental health problems. As one of the most widely cited researchers in the field, Dr. Richards forms part of the Digital Therapeutics Alliance, which leads the adoption and integration of digital therapeutics solutions into US healthcare.


Daniel Duffy, Ph.D.

Sr Manager Digital Health Scientist

Dan has been working as a researcher with SilverCloud® by Amwell for 7 years, and has managed, designed and executed on some of the pivotal trials that have substantiated the SilverCloud® suite of interventions as evidence-based. As a Sr Manager Digital Health Scientist, he currently contributes to the overall strategy and vision for the SilverCloud® science team, as well as supervises on the conduct of various research endeavours. He holds a PhD in psychology from Trinity College Dublin and is deeply passionate about the intersection between digital therapeutics and implementation science. Dan firmly believes that understanding the transition of digital therapeutics from “bench to bedside”, and the associated implementation factors that influence this process, will be the next big hurdle to overcome for digital healthcare.


Angel Enrique, Ph.D.

Sr Manager Digital Health Scientist

Angel is involved in the development of the strategy and vision for the SilverCloud® Science team, working in the design and execution of research studies. He also collaborates very closely with leading academics who are doing research with the SilverCloud® platform. He is passionate about the continuous innovation and optimization of digital mental health products. As per his background, he holds a Psychology degree and PhD in Clinical Psychology. He has been working at the intersect of technology and mental health for the last 10 years through a combination of academic and industry experience across Europe and US.


Siobhan Harty, Ph.D.

Principal Digital Health Scientist

Siobhán joined SilverCloud® by Amwell as a Principal Digital Health Scientist in 2021. She has a PhD in Psychology, and a Postgraduate Diploma in Statistics, and a number of additional years experience in academia as a postdoctoral researcher at Oxford University and Trinity College Dublin. During her time in academia she acquired expertise in a wide range of sophisticated methodologies spanning the fields of psychology, neuropsychology, and cognitive neuroscience, and has extensive experience in statistical and computational modelling. Here at SilverCloud® by Amwell, she is particularly passionate about optimising experimental design and data quality, as well as improving our understanding of the factors underpinning inter-individual differences in responsiveness to our CBT-programmes.


Katie Young, Ph.D.

Principal Digital Health Scientist

Katie joined SilverCloud® by Amwell as a Principal Digital Health Scientist in 2021. She has a doctorate in Psychiatry from Oxford University and research experience both as a postdoc at UCLA and as a lecturer at King’s College London. Katie’s research interests focus broadly around the mechanisms of interventions for anxiety and depression, particularly for young people. At SilverCloud® by Amwell, Katie is leading research on our newer Children and Young People’s programmes and is passionate about improving understanding and optimising effectiveness of digital mental health interventions for young people.


Garrett Hisler, Ph.D.

Digital Health Scientist

Garrett is a Digital Health Scientist on the team, with a PhD in Social/Personality psychology and additional expertise in sleep and circadian science and quantitative methods.


Catalina Cumpanasoiu, Ph.D.

Digital Health Scientist

Catalina joined SilverCloud® by Amwell as a Digital Health Scientist in 2020 after completing her PhD from Northeastern University, a joint degree between Bouvé College of Health Sciences and Khoury College of Computer Sciences with a focus on improving health through patient-facing, transdisciplinary, and innovative solutions. Coming from an interdisciplinary background, she has experience assessing the feasibility and impact of using new technologies in behavioral interventions for underserved populations. She is passionate about leveraging technology to improve health outcomes and using her expertise into designing, executing, and evaluating new research at SilverCloud® by Amwell.


Selin Akkol Solakoglu, Ph.D.

Digital Health Scientist

Selin is a Digital Health Scientist at SilverCloud® by Amwell and a clinical psychologist by training. She completed her master’s degree in Clinical Psychology in Turkey and has over 7 years of experience working as a psychotherapist. She has a PhD in Psychology at Trinity College Dublin, where she conducted research on adapting a digital intervention to reduce depression and anxiety symptoms in breast cancer survivors. Selin uses a mixed-methods approach in her research, combining quantitative and qualitative methods to broaden the understanding of the effectiveness and acceptability of digital interventions. She is particularly interested in digital health programs for populations with chronic illnesses and common mental health disorders such as anxiety and depression.


Adedeji Adegoke

Clinical Research Associate

Adedeji joined SilverCloud® by Amwell in 2020 as a Clinical Research Associate (Data Management). He completed his master's degree in Data Analytics from National College of Ireland where he conducted research on implementation of machine learning algorithms in detecting depression on social media, specifically Twitter. He specialises in data collection, management, and reporting of insightful findings for SilverCloud Research Team, his interest also lies in data science, advanced statistical technique and machine learning. In his free time, he likes to hike and play video games.